纵向课题: 山东省自然科学基金青年基金,ZR2021QB173,基于碳环和磷酸骨架修饰的非天然核酸作为人工遗传信息系统的研究,15万,2022.01-2024.12,主持。 皇冠(山东省科学院)人才科研项目,2023RCKY214,肿瘤靶向吉西他滨前药的设计、合成及活性研究,30万,2023.08-2024.07,主持。 济南市“新高校20条”,2022228088,生物信息指导下天然活性产物的定向制备,参加。 山东省重点研发计划(科技示范工程)项目,2022SFG0105,合成生物全产业链评价评估和标准体系建设,参加。
横向课题: 抗肿瘤吉西他滨前药合成及活性评价,2022.-1-2023.06,主持。
主要论文: Mengmeng Wang, Kunyu Qu, Peipei Zhao, Xin Yin, Yiwei Meng, Piet Herdewijn, Chao Liu*, Lixin Zhang*, Xuekui Xia*. Synthesis and anticancer evaluation of acetylatedlysine conjugated gemcitabine prodrugs. RSC Medicinal Chemistry, 2023, 14, 1572. Zhaohui Wen#, Mengmeng Wang#, Lingyun Li, Piet Herdewijn, Robert Snoeck, Graciela Andrei*, Zhaopeng Liu*, Chao Liu*.Synthesis and anti-SARS-CoV-2 evaluation of lipid prodrugs of β-D-N4-hydroxycytidine (NHC) and a 3′-fluoro-substituted analogue of NHC. Bioorganic Chemistry, 2023, 135, 106527.(共同第一作者) Mengmeng Wang, Puneet Srivastava, Chao Liu, Robert Snoeck, Graciela Andrei,Steven De Jonghe, Piet Herdewijn*.Synthesis and antiviral evaluation of cyclopentyl nucleoside phosphonates. European Journal of Medicinal Chemistry. 2018, 150, 616-625. Chunlei Li, Ziyi Zhou, Weitao Wang, Yanqiu Zhao, Xin Yin, Yiwei Meng, Peipei Zhao, Mengmeng Wang, Xueting Liu, Xinye Wang, Shenlin Wang, Biao Ren*, Lixin Zhang*, and Xuekui Xia*. Development of Antibacterial Peptides with Membrane-Disruption and Folate Pathway Inhibitory Activities against Methicillin-Resistant Staphylococcus aureus. Journal of Medicinal Chemistry, 2024, 67(2):1044-1060. Peipei Zhao, Hairong Liu, Qinghua Wu, Qingzhou Meng, Kunyu Qu, Xin Yin, Mengmeng Wang, Xiangxiang Zhao, Jun Qi, Yiwei Meng, Xuekui Xia*, Lixin Zhang*. Investigation of chetomin as a lead compound and its biosynthetic pathway[J]. Appl. Microbiol. Biotechnol., 2022, 106(8): 3093-3102.
专利: 一种HDAC和CTSL双激活的吉西他滨前药及其制备方法与应用,王盟盟 夏雪奎 曲昆玉 张立新 刘超 赵佩佩 殷欣 孟艺伟 皮特赫德维恩,202310047975.9
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