徐振上

发布时间:2022-09-09作者:出处:生物工程学院责任编辑:田中建

皇冠hg0086客户端(中国)登录入口官方网站/IOS安卓通用版

徐振上个人信息

徐振上

河北邢台

出生年月

1990418

职 称

副教授

政治面貌

中共党员

生物工程

导师类别

硕士研究生

导师

学历、学位

博士研究生

生物制药工程

工作信息

生物工程学院

隶属单位

皇冠hg0086客户端

通讯地点

山东省济南市长清区大学路3501号,xuzhenshang@126.com

学习、工作简历:

2007/09 - 2011/06 河北大学 生命科学学院 学士学位

2011/09 - 2014/06 皇冠 山东省微生物工程重点实验室 硕士学位

2014/09 - 2018/06 山东大学 微生物技术国家重点实验室 博士学位

2019/03 - 至今 皇冠山东省科学院 教师

主要研究方向:1)益生菌生理代谢特性及应用2)蛋白分泌表达机制及应用

本硕授课课程

讲授本科生课程:《生物化学》、《生物安全与伦理学》、《高级生化技术II》、《凝固型酸奶制作实验》

讲授研究生课程:

纵向课题

1.噬淀粉乳杆菌阿魏酸酯酶的非典型分泌机制研究,国家自然科学基金青年项目,25万,2020.1-2022.12

2.凝结芽孢杆菌中新型细菌素的鉴定和作用机制研究,皇冠(山东省科学院)青年博士合作基金,9.62万,2020.1-2021.12

3.植物乳杆菌中乳糖代谢的分子机制和应用研究,皇冠(山东省科学院)生物及生物化学ESI 学科开放课题,10万,2020.10-2022.10

4.阿魏酸酯酶在大肠杆菌中的高效分泌表达机制研究,生物基材料与绿色造纸国家重点实验室自主研究课题,3万,2020.10-2022.12

横向课题:

1.焦糖糖浆生产工艺开发,横向项目,10万,2021.7-2022.7

主要论文:

Zhe Wang; Chunhai Li; Xi He; Kang Xu; Zhipeng Xue; Ting Wang*; Zhenshang Xu*; Xinli Liu. Platycodon grandiflorum root fermentation broth reduces inflammation in a mouse IBD model through the AMPK/NF-κB/NLRP3 pathway. Food & Function. 2022, 13: 3946-3956.

Jiapeng Wang; Xuekui Xia; Peipei Zhao; Xi He; Susu Zhang; Ting Wang*; Zhenshang Xu*. High-level secretory production of lysostaphin in Escherichia coli mutant by codon optimization and atmospheric and room temperature plasma mutagenesis. LWT-Food Science and Technology. 2022, 165: 113744.

Zhenshang Xu; Yan Liang; Jian Kong; Susu Zhang; Xinli Liu*; Ting Wang*. A food-grade vector for Streptococcus thermophilus based on the α-complementation of β-galactosidase. Journal of Dairy Science. 2022, 105: 5641-5653.

Jiapeng Wang; Susu Zhang; Chunhai Li; Xinli Liu; Zhenshang Xu*; Ting Wang*. Efficient secretion of xylanase in Escherichia coli for production of prebiotic xylooligosaccharides. LWT-Food Science and Technology. 2022, 162: 113481.

Zhenshang Xu, Can Li, Yanxin Ye, Ting Wang*, Susu Zhang, Xinli Liu, The β-galactosidase LacLM plays the major role in lactose utilization of Lactiplantibacillus plantarum, LWT-Food Science and Technology, 2022, 153:112481.

Ting Wang, Zhe Wang, Zhipeng Yang, Xin Cui, Yan Liang, Zhenshang Xu*, Xinli Liu*, Effect of the fermentation broth of the mixture of Pueraria lobata, Lonicera japonica, Crataegus pinnatifida by Lactobacillus rhamnosus 217-1 on liver health and intestinal flora in mice with alcoholic liver disease induced by liquor, Frontiers in Microbiology. 2021, 12: 722171.

Zhenshang Xu, Rongling Zhang, Ting Wang*, Jian Kong*, The N-terminus of Lactobacillus amylovorus feruloyl esterase plays an important role in its secretion by Lactobacillus plantarum and Escherichia coli, Microbial Cell Factories, 2021, 20: 152.

Zhenshang Xu, Zhe Wang, X in Cui, Yan Liang, Ting Wang*, Jian Kong*, Peptide transporter-related protein 2 plays an important role in glutathione transport of Streptococcus theromophilus, Journal of Dairy Science, 2021, 104: 3990-4001.

Zhenshang Xu, Jian Kong, Susu Zhang, Ting Wang*, Xinli Liu*, Comparison of Enzyme Secretion and Ferulic Acid Production by Escherichia coli Expressing Different Lactobacillus Feruloyl Esterases, Frontiers in Microbiology, 11:569716, 2020, SCI, 二区, IF 5.6

Zhenshang Xu, Ting Wang, Susu Zhang*, Extracellular secretion of feruloyl esterase derived from Lactobacillus crispatus in Escherichia coli and its application for ferulic acid production, Bioresource Technology. 2019, 288: 121526.

Zhenshang Xu, Xinjun Zhao, Ting Wang*, The family 36 carbohydrate binding module enhances the efficiency of feruloyl esterase to release ferulic acid from destarched wheat bran, Journal Basic & Clinical Pharmacology & Toxicology, 2019, S1:9.

Ting Wang, Dong Yang, Zhenshang Xu*, Effects of fermented seaweed on the proliferation and wound healing of skin fibroblasts,Journal Basic & Clinical Pharmacology & Toxicology, 2019, S1:11.

Zhenshang Xu, Susu Zhang, Yingli Mu, Jian Kong*, Paenibacillus panacisoli enhances growth of Lactobacillus spp. by producing xylooligosaccharides in corn stover ensilages, Carbohydrate Polymers, 2018, 184:435-444.

Zhenshang Xu, Susu Zhang, Rongling Zhang, Shixu Li, Jian Kong*, The changes of dominant lactic acid bacteria and their metabolites during corn stover ensiling, Journal of Applied Microbiology, 2018, 125: 675-685.

Zhenshang Xu, Huiying He, Susu Zhang, Tingting Guo, Jian Kong*, Characterization of feruloyl esterases produced by the four lactobacillus species: L. amylovorus, L. acidophilus, L. farciminis and L. fermentum, isolated from ensiled corn stover. Frontiers in Microbiology, 2017, 8: 941.

Zhenshang Xu, Huiying He, Susu Zhang, Jian Kong*, Effects of inoculants Lactobacillus brevis and Lactobacillus parafarraginis on the fermentation characteristics and microbial communities of corn stover silage, Scientific Reports, 2017, 7: 13614.

Susu Zhang1, Zhenshang Xu1,Ting Wang, Jian Kong*, Endoglucanase improve the growth of homofermentative Lactobacillus spp. in ensilages, Journal of Biotechnology, 2019, 295: 55-62.

Ting Wang1, Zhenshang Xu1, Shiyi Lu, Min Xin and Jian Kong. Effects of glutathione on acid stress resistance and symbiosis between Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus. International Dairy Journal. 2016, 61: 22-28.


发明专利:

徐振上、王婷、刘新利、 张夙夙,一种双质粒食品级植物乳杆菌表达系统及其应用,国家发明专利,ZL201911223427.7

徐振上、刘新利、王婷、张夙夙,一种食品级植物乳杆菌表达系统及其在酸奶制备中的应用,国家发明专利,ZL201911223430.9

徐振上、王婷、张夙夙,耐碱耐热阿魏酸酯酶的制备方法及其应用,国家发明专利,ZL201910384386.3

徐振上、刘新利、王婷,一种食品级嗜热链球菌表达载体的构建方法,国家发明专利,ZL202010266247.3

徐振上、王婷、梁琰,一种食品级嗜热链球菌表达系统及其在酸奶制备中的应用,国家发明专利,ZL202010229538.5

徐振上、王婷、王家朋,一种复合微生态制剂及其在提高肠道短链脂肪酸中的应用,国家发明专利,ZL202110685223.6

徐振上、刘新利、王婷,一种转化乳糖生成乳果糖的植物乳杆菌工程菌株及其制备方法与应用,国家发明专利,CN202110968031.6

徐振上、刘新利、王婷、梁琰、薛志鹏,一种穿梭型食品级表达载体及其构建方法与应用,国家发明专利,CN202111192483.6

徐振上、王婷、刘新利、张夙夙,一种来源于乳酸乳球菌的L-阿拉伯糖异构酶及其在制备稀有糖中的应用,国际发明专利,2030021

徐振上、王婷、夏雪奎、王家朋、赵佩佩,一种利用大肠杆菌产溶葡萄球菌酶的方法,国家发明专利,CN202210279685.2

徐振上、王婷、刘新利、王家朋、严梦远、朱珂莹,一株高产溶葡萄球菌酶的大肠杆菌突变体,国家发明专利,CN202210680493.2

徐振上、王婷、张夙夙、严梦远、梁琰、刘新利,一种嗜热链球菌重组菌的构建方法及应用,国家发明专利,CN202210708079.8

科研获奖:

乳酸菌高密度发酵技术及产业化应用,山东省科学技术奖二等奖(7/7),山东省人民政府,2021.12.21

社会兼职:

中国微生物学会会员、美国乳品学会会员;Frontiers in Microbiology编辑;Food and FunctionFrontiers in Bioscience-Landmark、食品安全质量检测学报等杂志审稿专家。

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