主要课题： 国家重点研发计划子课题，2017YFF0209900，空气净化产品整机性能及安全性检测方法研究 国家重点研发计划“能感智能传感器”专项，2021YFB3201200，（病原微生物及疾病代谢标志物敏感元件关键技术及应用”项目子任务） 山东省自然科学基金创新发展联合基金项目，ZR2021LSW022，抗阿尔茨海默药物先导化合物的异源生物合成与作用机理研究 山东省重点研发计划（科技示范工程），2022SFGC0105，合成生物全产业链评价评估和标准体系建设（高通量通用生物元件评价及标准建立子课题） 山东省科技型中小企业创新能力提升工程，2021TSGC1293，通过构建生物相关酶催化诱导制备广谱抗癌药Larotrectinib关键手性片段的产业化研究 济南市“新高校20条”，2021GXRC062，海参活性肽的挖掘 济南市高校二十条，202228088，生物信息指导下活性天然产物的定向制备 皇冠生物及生物化学ESI培育学科开放课题，ESIBBC202013，青霉3,5-二甲基乙基烷酸衍生杂萜生物合成关键酶的功能研究 皇冠（山东省科学院）“揭榜制”项目子任务，2022JBZ01-06，生物智能制造关键技术及应用示范（生物信息指导下活性物质的生物合成） 皇冠（山东省科学院）科教产融合试点工程国际合作项目子课题，2022GH024，海参修复肽的生物创制 中瀚生物医药科技有限公司技术服务课题，swsfw05-2020-01，广谱抗癌药LOXO-101关键手性片段生物酶催化方法的建立及工业化应用研究 天宝牡丹生物科技有限公司技术服务课题，swsfw05-2021-02，牡丹花蕊甾醇类成分分析和功能评价 鲁南厚普制药有限公司，swskf05-2021-01，荆防颗粒抗衰老、抗炎、抗菌功效研究 鲁南厚普制药有限公司，swskf5-2023-01，荆防颗粒的抗衰老机制研究
主要论文： Chunlei Li, Ziyi Zhou, Weitao Wang, Yanqiu Zhao, Xin Yin, Yiwei Meng, Peipei Zhao, Mengmeng Wang, Xueting Liu, Xinye Wang, Shenlin Wang, Biao Ren*, Lixin Zhang*, and Xuekui Xia*. Development of Antibacterial Peptides with Membrane-Disruption and Folate Pathway Inhibitory Activities against Methicillin-Resistant Staphylococcus aureus. Journal of Medicinal Chemistry, 2024, 67(2):1044-1060. Qing-Zhou Meng, Xin-Zhu Wang, Huan-Qin Dai, Israa Assani, Meng-Ting, Zhang, Pei-Pei Zhao, Long-Fen Li, Xin Yin, Jun Qi, Yang Pan, Li-Xin, Zhang and Xue-Kui Xia. A gene cluster encoding a nonribosomal peptide synthetase-like enzyme catalyzes c-aromatic butenolides. Journal of Asian Natural Products Research, 2024, https://doi.org/10.1080/10286020.2024.2311150. 孟艺伟，赵燕秋，孟庆洲，吴清华，曲昆玉，赵佩佩，王盟盟，赵祥祥，代焕琴，殷欣*，夏雪奎*. 秀丽隐杆线虫模型在抗衰老研究中的应用. 2023, 45(1):9~15. Xin Yin, Yiwei Meng, Chenghong Sun, et al. Investigation of anti aging and anti infection properties of Jingfang Granules using the Caenorhabditis elegans model. Biogerontology, 2023, doi: 10.1007/s10522-023-10058-7. Mengmeng Wang, Kunyu Qu, Peipei Zhao, Xin Yin, Yiwei Meng, Piet Herdewijn, Chao Liu*, Lixin Zhang*, Xuekui Xia*. Synthesis and anticancer evaluation of acetylatedlysine conjugated gemcitabine prodrugs. RSC Medicinal Chemistry, 2023, 14, 1572. Xinzhu Wang, Qingzhou Meng, Haiyan Chen, Xin Yin, Huanqin Dai, Peipei Zhao, Yang Pan, Xuekui Xia & Lixin Zhang. Secondary metabolites isolated from Penicillium christenseniae SD.84 and their antimicrobial resistance effects. Natural Product Research, 2022, 6:1-9. Weitao Wang, Qingzhou Meng, Longfen Li, Weiyi Meng, Xin Yin, Peipei Zhao, Mengmeng Wang, Jingli Ren, Xuekui Xia, Chunlei Li. CGD-1, a defensin-related peptide derived from marine Chinese medicine Ostreae concha, inhibits the Gram-negative bacteria by membrane attack. TMR Pharmacology Research, 2023, 3(2):10. Peipei Zhao, Hairong Liu, Qinghua Wu, Qingzhou Meng, Kunyu Qu, Xin Yin, Mengmeng Wang, Xiangxiang Zhao, Jun Qi, Yiwei Meng, Xuekui Xia*, Lixin Zhang*. Investigation of chetomin as a lead compound and its biosynthetic pathway[J]. Appl. Microbiol. Biotechnol., 2022, 106(8): 3093-3102. 王红，殷欣，孟庆洲，曲昆玉，刘海溶，吴清华，杨梦，赵丽娅，戴美学，夏雪奎*. 基因组信息指导下海参共附生Penicillium sclerotiorum SD-36 嗜氮酮类化合物的挖掘. 中国海洋药物, 2022, 41(4): 1-11. Peipei Zhao, Meng Yang, Guoliang Zhu, Bo Zhao, Hong Wang, Hairong Liu, Xinzhu Wang, Jun Qi, Xin Yin, Lumin Yu, Yiwei Meng, Zhipu Li, Lixin Zhang*, Xuekui Xia*. Mollicellins S-U, Three New Depsidones from Chaetomium brasiliense SD-596 with Anti-MRSA Activities. Journal of Antibiotics. 2021(74): 317-323. Xinzhu Wang, Liya Zhao, Chao Liu, Jun Qi, Peipei Zhao, Zhaoming Liu, Chunlei Li, Yingying Hu, Xin Yin, Xin Liu, Zhixin Liao*, Lixin Zhang* Xuekui Xia*. New Tetramic Acids Comprising of Decalin and Pyridones from Chaetomium Olivaceum SD-80A with Antimicrobial Activity. Frontiers in Microbiology, 2020,10(2958) 殷欣，孟艺伟，赵丽娅，齐君，夏雪奎，高翠玲. 室内新风空气净化系统微生物多样性研究. 山东科学, 2020,33(5):99-105 C.L. Li, Y. Wen, Y. He, J.H. Zhu, X. Yin, J.N. Yang, L.X. Zhang*, L.Y. Song , X.K. Xia*, R.G. Yu. Purification and characterization of a novel β-1,3-glucanase from Arca inflata and its immune-enhancing effects. Food Chemistry, 2019, 290(30) , 1-9. C.L. Li, C.G Zhu, B. Ren, X. Yin, S. Shim, Y. Gao, J.H. Zhu, P.P. Zhao, C.H. Liu, R.M. Yu, X.k. Xia*, L.X.Zhang*. Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus. European Journal of Medicinal Chemistry. 2019, 183, 111686. Yin X, Li JF, Wang CJ, et al. Improvement in the thermostability of a type A feruloyl esterase, AuFaeA, from Aspergillus usamii by iterative saturation mutagenesis. Appl Microbiol Biotechnol, 2015, 99:10047–10056. Yin X, Hu D, Li JF, et al. Contribution of disulfide bridges to the thermostability of a type A feruloyl esterase from Aspergillus usamii. PLoS ONE, 2015, 10(5): e0126864. Yin X, Li JF, Wang JQ, et al. Enhanced thermostability of a mesophilic xylanases by N-terminal replacement designed by molecular dynamics simulation. J Sci Food Agric, 2013, 93(12): 3016-3023. Yin X, Yao Y, Wu MC, et al. A unique disulfide bridge of the thermophilic xylanase SyXyn11 plays a key role in its thermostability. Biochemistry (MOSCOW), 2014, 79(6): 531-537. Yin X, Gong YY, Wang JQ, et al. Cloning and expression of a family 10 xylanase gene (Aoxyn10) from Aspergillus oryzae in Pichia pastoris. J Gen Appl Microbiol, 2013, 59: 405-415. Zeng Y, Yin X, Wu MC, et al. Expression of a novel feruloyl esterase from Aspergillus oryzae in Pichia pastoris with esterification activity. J Mol Catal B-Enzym, 2014, 110: 140–146. (共同第一作者) Gong YY, Yin X, Zhang HM, et al. Cloning, expression of a feruloyl esterase from Aspergillus usamii E001 and its applicability in generating ferulic acid from wheat bran. J Ind Microbiol Biotechnol, 2013, 40(12): 1433-1441. (共同第一作者)
专利： 抗菌肽H5-p5及其制备方法和应用，夏雪奎 李春磊 张立新 殷欣 齐君 赵佩佩 刘昌衡 孟艺伟 赵丽娅 韩雅 杨梦 王红，ZL201910425744.0
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