本硕授课课程: 讲授本科生课程:科技发展与学科专业概论课、开放实验课 讲授研究生课程:学科前沿专题课
纵向课题: (1)国家科学技术部,“一带一路”创新人才交流外国专家项目,“抗神经系统疾病活性物质***”,2021.01-2022.12,30万,结题,主持; (2)济南市科学技术局,济南市“新高校20条”高校院所科研带头人工作室,“抗癫痫药物高效筛选技术研发及应用”,2022.01-2024.12,20万,在研,主持; (3)国家科学技术部,国家高端外国专家引进计划,“基于冠状病毒关键抗原***”,2020.01-2021.01,50万元,结题,主持; (4)国家自然科学基金委员会,国家自然科学基金青年基金,“EYA2通过与PAX6相互作用调控乳腺癌侵袭和转移的机制研究”,2019.01-2021.12,21万元,结题,主持; (5)皇冠(山东省科学院),科教产融合试点工程基础研究类项目,“高通量筛选体系导向的抗癫痫活性化合物筛选分析和作用机制研究”,2022.01-2023.12,30万元,在研,主持; (6)皇冠(山东省科学院),科教产融合试点工程重大创新专项,“生物智能制造关键技术及应用示范”,2022.08-2024.08,1200万元,在研,子课题负责人; (7)皇冠(山东省科学院),校(院)科教产融合创新试点工程,“基于斑马鱼模型的早期活性筛选与安全性评价关键技术研究”,2020.01-2021.12,481.2万元,结题,子课题负责人; (8)山东省科学院青年基金,“由关键蛋白相互作用介导的乳腺癌侵袭和转移的调控机制研究”,2018.01-2019.12,10万元,结题,主持; (9)山东省科学院科技发展基金,“EYA2通过与PAX6相互作用调控乳腺癌侵袭和转移的机制研究”,2019.01-2021.12,10万元,结题,主持; (10)中国科学院沈阳分院—山东省科学院青年科学家合作伙伴项目,“没药烯工程菌株的优化及没药烯毒性活性评价”,2017.06-2019.06,3万元,结题,主持; (11)皇冠,校(院)生物及生物化学ESI培育学科开放课题,“防治帕金森病、癫痫活性物质高效筛选技术及新药先导化合物研究”,2020.10-2022.09,10万元,结题,主持; (12)山东省科学院,人才专项“B类优秀博士引进”,2016.12-2019.12,15万元,结题,主持。 (13)山东省科学技术厅,山东省自然科学基金重大基础研究项目,“针对重大疾病的深海微生物药用活性分子的高效发现与作用机制研究”,2022.01- 2024.12,200万,在研,参与; (14)山东省科学技术厅,山东省外专双百计划“抗神经系统疾病活性物质高效***”,2020.12-2023.12,300万,在研,核心成员; (15)济南市科学技术局, 济南市“新高校20条”高校院所引进高端人才项目,“神经保护天然活性成分的筛选及功能产品研发”,2022.01-2024.12,100万元,在研,核心成员; (16)山东省科学技术厅,山东省自然科学基金,“褪黑素受体在昼行动物斑马鱼视网膜中的表达及对自感光神经节细胞光反应的调制”,2018.03-2020.06,5万元,结题,参与; (17)皇冠(山东省科学院)科教产融合创新试点工程,“军民两用新型碳基快速止血材料研发”,2020.01-2021.12,154万元,结题,核心成员; (18)山东省科学技术厅,山东省高端外国专家项目,“基于斑马鱼癫痫模型***”,2019.01-2019.12,20万元,结题,核心成员; (19)山东省科学技术厅,山东省重点研发计划(重大),“西洋参特色中药材产业链关键技术研究及健康产品研发”,2019.12-2021.12,350万元,结题,参与; (20)山东省科学院国际科技合作项目,“新型碳基止血材料的研发”,2019.01-2020.12,130万元,结题,核心成员; (21)山东省科学技术厅,山东省中青年科学家科研奖励基金,“海绵及其共附生微生物来源的心血管药物先导化合物的发现”,2019.08-2024.12,100万元,在研,参与; (22)山东省科学技术厅,山东省重点研发计划,“以虾头废弃物为原料的多不饱和脂肪酸磷脂制备关键技术研究”,2019.01-2020.12,15万元,结题,参与; (23)山东省科学院,山东省科学院国际科技合作项目,“抗难治性癫痫的I类新药的研究与开发”,2019.01-2020.12,30万元,结题,参与; (24)山东省科学技术厅,山东省外专双百计划,“聚乙二醇化的生物碱类***”,2019.12-2022.12,300万,结题,核心成员
论文(近五年,以第一作者或通讯作者发表的SCI论文): 1.Gao X, Zhang B, Zheng Y, Liu X, Rostyslav P, Finiuk N, Sik A, Stoika R, Liu K, Jin M*: Neuroprotective effect of chlorogenic acid on Parkinson's disease like symptoms through boosting the autophagy in zebrafish. European journal of pharmacology 2023, 956:175950. 2.Wang LZ#, Mou L#, Guan SB, Wang CS, Sik A, Stoika R, Liu KC, Jin M*: Isoliquiritigenin induces neurodevelopmental-toxicity and anxiety-like behavior in zebrafish larvae. Comp Biochem Phys C 2023, 266. 3.Jin M#, Shi R#, Gao D, Wang B, Li N, Li X, Sik A, Liu K*, Zhang X*: ErbB2(pY) (-1248) as a predictive biomarker for Parkinson's disease based on research with RPPA technology and in vivo verification. CNS neuroscience & therapeutics 2023. 4.Xia L, Jin M*: Editorial: Neuropharmacological and neurotoxicological advances using in vivo non-mammalian model organisms. Frontiers in neuroscience 2023, 17:1264745. 5.Wang MF#, Ye HC#, Jiang P, Liu JB, Wang BK, Zhang SS, Sik A, Li N*, Liu KC*, Jin M*: The alleviative effect of Calendula officinalis L. extract against Parkinson's disease-like pathology in zebrafish via the involvement of autophagy activation. Frontiers in neuroscience 2023, 17. 6.Shi R#, Gao D#, Stoika R, Liu K, Sik A, Jin M*: Potential implications of polyphenolic compounds in neurodegenerative diseases. Critical reviews in food science and nutrition 2022:1-24. 7.Song Y, Liu S, Jiang X, Ren Q, Deng H, Paudel YN, Wang B, Liu K, Jin M*: Benzoresorcinol induces developmental neurotoxicity and injures exploratory, learning and memorizing abilities in zebrafish. The Science of the total environment 2022, 834:155268. 8.Ren Q#, Jiang X#, Zhang S#, Gao X, Paudel YN, Zhang P, Wang R, Liu K, Jin M*: Neuroprotective effect of YIAEDAER peptide against Parkinson's disease like pathology in zebrafish. Biomedecine & pharmacotherapy 2022, 147:112629. 9.Ren Q#, Jiang X#, Paudel YN, Gao X, Gao D, Zhang P, Sheng W, Shang X, Liu K, Zhang X*, Jin M*: Co-treatment with natural HMGB1 inhibitor Glycyrrhizin exerts neuroprotection and reverses Parkinson's disease like pathology in Zebrafish. Journal of ethnopharmacology 2022, 292:115234. 10.Li X#, Gao D#, Paudel YN, Li X, Zheng M, Liu G, Ma Y, Chu L, He F*, Jin M*: Anti-Parkinson's Disease Activity of Sanghuangprous vaninii Extracts in the MPTP-Induced Zebrafish Model. ACS chemical neuroscience 2022, 13(3):330-339. 11.Wang R#, Ren Q#, Gao D#, Paudel YN, Li X, Wang L, Zhang P, Wang B, Shang X*, Jin M*: Ameliorative effect of Gastrodia elata Blume extracts on depression in zebrafish and cellular models through modulating reticulon 4 receptors and apoptosis. Journal of ethnopharmacology 2022, 289:115018. 12.Jin M#, Li N#, Sheng W, Ji X, Liang X*, Kong B, Yin P, Li Y, Zhang X, Liu K*: Toxicity of different zinc oxide nanomaterials and dose-dependent onset and development of Parkinson's disease-like symptoms induced by zinc oxide nanorods. Environment international 2021, 146:106179. 13.Ren Q#, Gao D#, Mou L#, Zhang S, Zhang M, Li N, Sik A, Jin M*, Liu K*: Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish. European journal of pharmacology 2021, 912:174589. 14.Dang J#, Paudel YN#, Yang X#, Ren Q, Zhang S, Ji X, Liu K, Jin M*: Schaftoside Suppresses Pentylenetetrazol-Induced Seizures in Zebrafish via Suppressing Apoptosis, Modulating Inflammation, and Oxidative Stress. ACS chemical neuroscience 2021, 12(13):2542-2552. 15.Ji X#, Wang B#, Paudel YN#, Li Z, Zhang S, Mou L, Liu K, Jin M*: Protective Effect of Chlorogenic Acid and Its Analogues on Lead-Induced Developmental Neurotoxicity Through Modulating Oxidative Stress and Autophagy. Frontiers in molecular biosciences 2021, 8:655549. 16.Jin M, Dang J, Paudel YN, Wang X, Wang B, Wang L, Li P, Sun C, Liu K*: The possible hormetic effects of fluorene-9-bisphenol on regulating hypothalamic-pituitary-thyroid axis in zebrafish. The Science of the total environment 2021, 776:145963. 17.Li X, Dang J, Li Y, Wang L, Li N, Liu K, Jin M*: Developmental neurotoxicity fingerprint of silica nanoparticles at environmentally relevant level on larval zebrafish using a neurobehavioral-phenomics-based biological warning method. The Science of the total environment 2021, 752:141878. 18.Wang L#, Sheng W#, Tan Z, Ren Q, Wang R, Stoika R, Liu X, Liu K, Shang X*, Jin M*: Treatment of Parkinson's disease in Zebrafish model with a berberine derivative capable of crossing blood brain barrier, targeting mitochondria, and convenient for bioimaging experiments. Comparative biochemistry and physiology Toxicology & pharmacology : CBP 2021, 249:109151. 19.Jin M, Ji X, Stoika R, Liu K, Wang L*, Song Y: Synthesis of a novel fluorescent berberine derivative convenient for its subcellular localization study. Bioorganic chemistry 2020, 101:104021. 20.Jin M, Gao D, Wang R, Sik A, Liu K*: Possible involvement of TGFbeta-SMAD-mediated epithelialmesenchymal transition in prometastatic property of PAX6. Oncology reports 2020, 44(2):555-564. 21.Jin M#,*, Zhang B#, Sun Y#, Zhang S, Li X, Sik A, Bai Y*, Zheng X*, Liu K*: Involvement of peroxisome proliferator-activated receptor gamma in anticonvulsant activity of alpha-asaronol against pentylenetetrazole-induced seizures in zebrafish. Neuropharmacology 2020, 162:107760. 22.Zhang S, Yu Z, Xia J, Zhang X, Liu K, Sik A, Jin M*: Anti-Parkinson's disease activity of phenolic acids from Eucommia ulmoides Oliver leaf extracts and their autophagy activation mechanism. Food & function 2020, 11(2):1425-1440. 23.Zhang B#, Wang L#, Ji X#, Zhang S, Sik A, Liu K, Jin M*: Anti-Inflammation Associated Protective Mechanism of Berberine and its Derivatives on Attenuating Pentylenetetrazole-Induced Seizures in Zebrafish. Journal of neuroimmune pharmacology 2020, 15(2):309-325. 24.Shang X#, Ji X#, Dang J, Wang L, Sun C, Liu K, Sik A, Jin M*: alpha-asarone induces cardiac defects and QT prolongation through mitochondrial apoptosis pathway in zebrafish. Toxicology letters 2020, 324:1-11. 25.Shang X*, You C, Li X, Yuan L, Jin M*, Zhang X*: Involvement of 5-HT2 serotonin receptors in cognitive defects induced by aristolochic acid I in mice. Toxicology 2020, 447:152624. 26.Li X, Ji X, Wang R, Zhao J, Dang J, Gao Y, Jin M*: Zebrafish behavioral phenomics employed for characterizing behavioral neurotoxicity caused by silica nanoparticles. Chemosphere 2020, 240:124937. 27.Jin M, Xiao Z, Zhang S, Men X, Li X, Zhang B, Zhou T, Hsiao CD, Liu K*: Possible involvement of Fas/FasL-dependent apoptotic pathway in alpha-bisabolol induced cardiotoxicity in zebrafish embryos. Chemosphere 2019, 219:557-566. 28.Jin M#, Ji X#, Zhang B, Sheng W, Wang R, Liu K*: Synergistic effects of Pb and repeated heat pulse on developmental neurotoxicity in zebrafish. Ecotoxicology and environmental safety 2019, 172:460-470. 29.Li X, Kong H, Ji X, Gao Y, Jin M*: Zebrafish behavioral phenomics applied for phenotyping aquatic neurotoxicity induced by lead contaminants of environmentally relevant level. Chemosphere 2019, 224:445-454. 30.Li X, Zhang B, Li N, Ji X, Liu K*, Jin M*: Zebrafish neurobehavioral phenomics applied as the behavioral warning methods for fingerprinting endocrine disrupting effect by lead exposure at environmentally relevant level. Chemosphere 2019, 231:315-325. 31.Jin M, Sheng W, Han L, He Q, Ji X, Liu K*: Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish. Fish & shellfish immunology 2018, 83:26-36. 32.Jin M, He Q, Zhang S, Cui Y, Han L*, Liu K*: Gastrodin Suppresses Pentylenetetrazole-Induced Seizures Progression by Modulating Oxidative Stress in Zebrafish. Neurochemical research 2018, 43(4):904-917.
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