课题： 纵向课题：承担国家重点研发计划《基于生物效应和DNA 身份证的中成药质量控制技术研究及其应用》；山东省重大科技创新工程项目《西洋参特色中药材产业链关键技术研究及健康产品研发》；山东省科学院青年基金项目《基于氧化应激-线粒体凋亡途径的11-羰基-β-乙酰乳香酸心脏毒性作用机制研究》。 横向课题：《利用斑马鱼模型评价传统阿胶的系列生物活性》，《五个保护剂对何首乌肝毒性的配伍减毒作用研究》等。 近三年代表性论文： 1. Zhaoyi Wang#, Qing Xia#, Xin Liu, Wenxue Liu, Wanzhen Huang, Xue Mei, Jun Luo, Mingxu Shan, Ruichao Lin, Dixin Zou, Zhiqiang Ma. Phytochemistry, pharmacology, quality control and future research of Forsythia suspensa (Thunb.) Vahl: A review. Journal of ethnopharmacology, 2018, 210:318-339. 2. Qing Xia, Lingying Wei, Yun Zhang, Haotian Kong, Yongping Shi, Xue Wang, Xiqiang Chen, Liwen Han, Kechun Liu*. Psoralen Induces Developmental Toxicity in Zebrafish Embryos/Larvae Through Oxidative Stress, Apoptosis, and Energy Metabolism Disorder. Front Pharmacol. 2018, 18;9:1457. 3. Liwen Han#, Qing Xia#, Lei Zhang, Xuanming Zhang, Xiaobin Li, Shanshan Zhang, Lizhen Wang, Changxiao Liu*, Kechun Liu*. Induction of developmental toxicity and cardiotoxicity in zebrafish embryos/larvae by acetyl-11-keto-β-boswellic acid (AKBA) through oxidative stress. Drug Chem Toxicol. 2019, 28:1-8. 4. Zhenzhen Song, Yun Zhang, Huazheng Zhang, R Samuel Rajendran, Rongchun Wang, Chung-Der Hsiao, Jianheng Li*, Qing Xia*, Kechun Liu*. Isoliquiritigenin Triggers Developmental Toxicity and Oxidative Stress-Mediated Apoptosis in Zebrafish embryos/larvae via Nrf2-HO1/JNK-ERK/ mitochondrion Pathway. Chemosphere. 2020, 246:125727. 5. Qing Xia, Kechun Liu, Zhili Jia, Xiaobin Li, Shanshan Zhang, Liwen Han, Guijin Sun, Chung-Der Hsiao, Yun Zhang. The hepatoprotective effects of squid gonad phospholipids on fatty liver disease in zebrafish. Food Bioscience. 2020, 35 (2020):100592. doi:10.1016/j.fbio.2020.100592 6. 夏青;韩利文;张云;何秋霞;张姗姗;高静静;刘可春;屠鹏飞. 基于斑马鱼模型的柴胡皂苷a保肝作用与肝毒性研究. 中国中药杂志, 2019, 44(13): 2662-2666. 专利： 一种用于研究斑马鱼再生修复功能的装置。 王雪；刘可春；张云；韩利文；陈锡强；夏青；王荣春；王希敏。CN209446881U。 |
